ARCHIVE # 4: 554 ARTICLES (NOV -SEPT 2006)

	Dr. Timothy L. Vollmer Chairman, Division of Neurology Barrow Neurological Institute St. Joseph's Hospital and Medical Center
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Chairman, Division of Neurology
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Saturday, September 16, 2006

Potential for interferon Beta-induced serum antibodies in MS to inhibit endogenous interferon-regulated chemokine/cytokine responses...READ MORE:
[Abstract: National Institutes of Health - Entrez PubMed]
"BACKGROUND: A proportion of patients with multiple sclerosis (MS) receiving systemic interferon beta therapy will develop serum neutralizing antibodies (NAbs) that can reduce the activity of the drug"...CONCLUSION: High-titer NAbs to interferon beta may block endogenous IFN-beta function and alter the chemokine/cytokine microenvironment within the central nervous system, thereby modulating the profile and course of the local inflammatory response.

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