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Tuesday, November 07, 2006
"Critical Outcome Technologies Inc. announces the final selection of its library of orally available lead compounds for the treatment of acute MS" PRESS RELEASE
" LONDON, Ontario--(CCNMatthews - Nov. 7, 2006) - Critical Outcome Technologies Inc. (TSX-V: COT), a computational drug discovery and pre-clinical drug development company, has completed the discovery, optimization and final selection of its library of lead compounds for the oral treatment of acute Multiple Sclerosis. The compounds have been engineered to be orally available, have low toxicity, cross the blood brain barrier and selectively inhibit Vascular Endothelial Growth Factor (VEGF-R) and Platelet Derived Growth Factor (PDGF-R) receptor kinases. The first four lead candidates are now being synthesized at Dalton Pharma Services, Toronto, Canada, prior to undergoing efficacy and toxicity testing in a validated animal model of acute allergic encephalitis. Critical Outcome Technologies Inc. (COTI) expects the synthesis to be completed by the end of January 2007..." |